SNURMET-500 (Metformin) 500mg x 15 tablets
Action and Effects
Promotes sugar utilization in muscles and inhibits sugar production in the liver to reduce blood sugar (blood glucose level).
Usually used to treat type 2 diabetes.
Precautions for Use
If you have previously experienced allergic symptoms such as itching or rashes after using the drug. If you have previously had lactic acidosis. , before or after surgery, trauma, malnutrition, starvation, debilitation, pituitary gland dysfunction, or adrenal gland dysfunction.
Pregnant, possibly pregnant, breastfeeding
If you are using other medications (be careful of other over-the-counter medicines and foods you are using, as the effects of each medication may be strengthened or weakened).
Dosage and Administration
Normally, adults should start by taking 1 tablet (500mg of the active ingredient) 2-3 times a day, just before or after meals. Take 1.5 to 3 tablets (750 mg to 1,500 mg) per day in 2 to 3 divided doses. Children aged 10 years or older should take 1 tablet (500 mg of the active ingredient) per day in 2 to 3 divided doses. Start by taking the tablet immediately before or after a meal. The amount is determined based on the effect, but usually 1 to 3 tablets (500 mg to 1,500 mg) per day in 2 to 3 divided doses. The dosage may be increased depending on the symptoms, but the maximum daily dose is 4.5 tablets (2,250 mg) for adults and 4 tablets (2,000 mg) for children. Be sure to follow the instructions for taking the medicine.
If you miss a dose, take the next dose at the scheduled time. Never take two doses at once.
If you accidentally take more than the recommended dose, consult a doctor or pharmacist.
Do not stop taking the medicine on your own judgment, regardless of your doctor’s instructions.
Side effects
The main side effects reported are diarrhea, nausea, rash, itching, loss of appetite, and abdominal pain. If you notice any of these symptoms, consult your doctor or pharmacist. In rare cases, the following symptoms may occur and may be early symptoms of the side effects listed in [ ].
– Intestinal symptoms such as nausea and vomiting, fatigue, muscle pain [lactic acidosis]
– Weakness, drowsiness, sweating [hypoglycemia]
– General fatigue, loss of appetite, yellowing of the skin and whites of the eyes [liver dysfunction, jaundice]
– Pain, stiffness, and numbness in the stomach muscles of the hands and feet [rhabdomyolysis]
The above side effects are not all-inclusive. If you experience any other symptoms, consult your doctor or pharmacist.
Metformin may promote anti-aging
Metformin, which has been used in many diabetes treatments, has been tested in humans for its anti-aging properties.
Researchers believe that metformin, which has already been widely used to treat diabetes for about 60 years, may have many additional health concerns. These conditions include inflammation, oxidation, reduced autophagy, cellular senescence and apoptosis. Experts are considering whether metformin use may improve gene expression in older people who have impaired glucose tolerance versus younger people.
“We want to change the habit of neglecting disease so much by caring about the treatment of older people,” Barzilian told Economics of Medicine. “We prevent aging, and thereby the development of multiple diseases,” she added. The researchers published that patients cured with metformin rather than diabetes lived longer, and they recommend that metformin is also an aid to diabetes patients.
Metformin appears to increase the number of oxygen molecules released into cells, boosting robustness and longevity.
The Food and Drug Administration will green clinical trials in the United States for what is known as targeting aging in metformin studies to analyze time outside of treating diabetes. Researchers will give metformin to about 3,000 elderly people who suffer from something like cancer, heart disease, or cognitive problems, or are at high risk for developing them. They will then track it for six years to see if it is a preventive drug for aging diseases. Eventually they will also see if it will prevent diabetes for a long time and temporarily. It will be a double-blind placebo-controlled study.
Metformin has already been proven to slow the aging process in certain microorganisms and dairy animals. Barzilai hopes that it will be useful in stemming aging and disease breakthroughs and progress, and that the FDA will approve it for its instructions and find better treatments.
How metformin intake leads to longevity
There are currently two active routes for the mechanism of longevity effects.
The first is the activation of the sirtuin gene. This has the effect of activating the sirtuin gene, such as NMN and resveratrol. The second
The route is to inhibit an enzyme called mTOR. When this enzyme is inhibited, autophagy, a mechanism for cleaning the inside of cells, works, restoring the function and efficiency of cells and resulting in a longevity effect. To inhibit mTOR, you should not normally fast. By restricting carbohydrates as well as protein, mTOR is inhibited and autophagy occurs. That’s tough! Humans want to activate autophagy in other ways. Foods that inhibit mTOR include caffeine, which is found in coffee, and the diabetes drugs metformin and rapamycin also inhibit mTOR. Inhibiting mTOR increases longevity Inhibiting mTOR reduces age-related diseases and tends to increase longevity. Metformin inhibits mTOR to increase longevity, and has an anti-inflammatory effect that inhibits TNFα, IL-6, and NF-kB. Inflammation always involves the generation of active oxygen, so anti-inflammation and antioxidants are the basis for preventing aging beyond age. Because it has the effect of inhibiting glycation, it leads to the improvement of glycation, which is the cause of aging, and is also effective in anti-aging.
Risks of long-term metformin intake
Long-term metformin administration can cause a deficiency of vitamin B12.
As a countermeasure, it is recommended that people who drink alcohol, especially those who consume vitamin B12, take metformin together with B vitamins, as vitamin B12 is consumed quickly.
We recommend taking supplements beforehand.
Water-soluble vitamins, such as vitamin B and C, will only cause diarrhea even if taken in large quantities, so we recommend that you take them knowing your own limits.
Any unused in the body will be excreted in the urine.
• Inhibiting mTOR increases longevity•
Metformin suppresses mTOR
• A large-scale epidemiological study is currently being conducted in the United States to look at the longevity effect
• Metformin is also an anti-glycation agent
• The risk of metformin is vitamin B12 deficiency
